The TERT gene provides instructions for making one component of an enzyme called telomerase. Learn about this gene and related health conditions.

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises …

In this review, we summarise the function and structure of telomerase reverse transcriptase ( TERT ) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations …

Nov 14, 2025 · Complete information for TERT gene (Protein Coding), Telomerase Reverse Transcriptase, including: function, proteins, disorders, pathways, orthologs, and expression.

Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase (TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in most normal human …

Jan 26, 2024 · Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase …

Aug 2, 2025 · The TERT gene, or telomerase reverse transcriptase, provides instructions for making a protein that is a core component of the telomerase enzyme. Telomerase helps maintain telomeres, …

Nov 19, 2020 · In most human cancers, telomerase is reactivated during carcinogenesis by expression of the catalytic subunit telomerase reverse transcriptase (TERT). TERT plays a key role in cancer …

A gene that makes a protein involved in maintaining telomeres (the ends of chromosomes). Mutations (changes) in the TERT gene have been found in some types of cancer, including melanoma, acute …

Dec 20, 2023 · The protein encoded by the Tert gene, telomerase reverse transcriptase (TERT), is the catalytic subunit of the telomerase enzyme and is responsible for the addition of telomeric repeats to …