Serine and one-carbon metabolism in cancer - Nature
Sep 16, 2016 · Serine supports many biosynthetic pathways, including the one-carbon cycle. This Review discusses how cancer cells acquire and use serine, and explores novel therapeutic …
Impaired glycolysis-derived serine metabolism as a key driver of ...
Dec 4, 2025 · Previous studies showed inhibition of glycolytic enzyme pyruvate kinase M2 disrupts podocyte function. The study shows that PGK1-serine axis regulates and drives aging and damage …
The ins and outs of serine and glycine metabolism in cancer
Jan 28, 2021 · Geeraerts et al. explore the centrality of serine and glycine metabolism to cancer survival, and how targeting the de novo serine and glycine synthesis pathways can complement current …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable
Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase.
Functional profiling of serine, threonine and tyrosine sites
Sep 23, 2024 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in ...
Species-specific serine metabolism differentially controls natural ...
Aug 14, 2025 · Serine metabolism was enhanced by cytokine activation in both species, but functional profiling indicated that activated human and mouse NK cells differed in their utilization of serine to …
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and
May 6, 2025 · Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis …
Cellular redox state constrains serine synthesis and ... - Nature
Sep 16, 2019 · The de novo serine synthesis pathway is upregulated in many cancers. However, even cancer cells with increased serine synthesis take up large amounts of serine from the environment 1, …
An epidermal serine sensing system for skin healthcare - Nature
Mar 18, 2025 · Serine is an important biomarker for skin healthcare. Here, the authors introduce a portable epidermal sensing system capable of direct sampling and in situ quantification of serine on …
Limiting serine availability during tumor progression promotes muscle ...
Dec 21, 2024 · Here, we demonstrate that decreased serine availability during tumor progression promotes myotubes diameter reduction in vitro and induces muscle wasting in in vivo mice models.