The purpose of the Manual on Uniform Traffic Studies (MUTS) is to establish minimum standards for conducting traffic engineering studies on roads under the jurisdiction of the Department of …

MutS is a mismatch DNA repair protein, originally described in Escherichia coli. Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse …

Oct 3, 2022 · MutS recognizes mismatched nucleotides forming ATP-bound sliding clamps, which subsequently load MutL sliding clamps that coordinate MMR excision.

To initiate MMR, MutS must first locate and recognize base pair mismatches or base insertion/deletions (IDLs) in duplex DNA. MutS proteins are dimers with DNA binding and …

MutS, a DNA mismatch-binding protein, seems to be a promising tool for mutation detection. We present three MutS based approaches to the detection of point mutations: DNA retardation, …

Jul 7, 2022 · For the past 2 decades, molecular mechanisms of MutS-I proteins have been proposed on the basis of structural information. Bacterial MutS is a homodimeric protein, …

Three of these proteins are essential in detecting the mismatch and directing repair machinery to it: MutS, MutH and MutL (MutS is a homologue of HexA and MutL of HexB). MutS forms a …

Here we present a crystal structure of the MutS/MutL complex using a site-specifically crosslinked complex and examine how large conformational changes lead to activation of MutL.

Jun 25, 2020 · Mutations in the proteins MutSα and MutLα that initiate MMR are responsible for Lynch syndrome, the most common hereditary cancer. We present results showing surprising …

Apr 7, 2025 · MutS is a regional lesion sensor that specifically recognises mismatches in DNA. It forms a complex with MutL, a weak ATPase that mediates protein-protein interactions during …