JAK激酶 - 维基百科，自由的百科全书
JAK激酶 （英語： Janus kinase，缩写 JAK）是一个细胞内非受体 酪氨酸激酶 家族，介导 细胞因子 产生的信号，并通过 JAK-STAT信号通路 传递下去，在细胞分化、增殖、免疫应答、造血功能及炎症 …
JAK-STAT信号通路全面梳理：信号传导、激活与调控、主要基因、信号 …
JAK（Janus激酶）家族成员包括JAK1、JAK2、JAK3和TYK2。 它们是细胞膜上受体激酶的下游信号传导组分，在信号转导过程中起到关键作用。
JAK-STAT_百度百科
JAK-STAT信号通路是细胞内由Janus激酶（JAKs）、信号转导和转录激活蛋白（STATs）及细胞因子受体组成的信号传导机制。 该通路通过受体二聚化触发，经历JAK交叉磷酸化、STAT募集与磷酸化 …
干货分享 | 带你快速入门JAK/STAT signaling pathways信号通路
May 16, 2024 · Janus激酶（JAK）信号转导和转录激活因子（JAK-STAT）途径是一种进化上保守的信号通路， 由细胞因子刺激激活，使细胞外信号通过细胞膜传递到细胞核，引起DNA转录的改变，在几 …
What are JAK inhibitors and how do they work? - Drugs.com
Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …
The Safety and Efficacy of JAK Inhibitors: Have We Found the Right ...
May 15, 2025 · Although the new generation of JAK inhibitors is designed to increase specificity for particular JAK subtypes, the current selective categorization is largely based on in vitro trials and …
The JAK-STAT pathway at 30: Much learned, much more to do
Oct 13, 2022 · The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a …
Janus Kinase - an overview | ScienceDirect Topics
The JAK family consists of four types: JAK1, JAK2, JAK3, and TYK2. Activation of JAK stimulates the expression of signal transducer and activator of transcription (STAT). Also, STAT can be stimulated …
We highlight the use of JAK inhibitors in clinical scenarios, including haematology-oncology, rheumatology, dermatology, and gastro enterology, as they are the most established in these …
Science：小型临床试验表明JAK抑制剂与抗PD-1免疫疗法的组合使用有 …
相关研究结果发表在2024年6月21日的Science期刊上，论文标题为“Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients”。