Fruit flies with genetic mutations that severely reduce sleep show enhanced performance in olfactory memory tasks, ...

Fruit fly mutants that have severe sleep deficits perform better at olfactory learning and memory tasks, according to a study published March 20th in ...

Fruit fly mutants that have severe sleep deficits perform better at olfactory learning and memory tasks, according to a study published in the open-access journal PLOS Biology by Sheng Huang and ...

Researchers have revealed for the first time how a key protein linked to Parkinson's mutates, leads to cell death in the ...

VIP stimulation leads to cAMP production and subsequent activation of protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) (15, 28, 29). Both of these activated proteins are ...

In vitro extracellular exposure to PGE2 could directly and dose-dependently inhibit the potassium channel Kv2.2. In vitro pharmacology revealed that this inhibition occurs through the EP2/4 receptors, ...

The scaffold protein JIP1 plays a key role in the c-Jun N-terminal kinase (JNK) signaling pathway by facilitating the colocalization of multiple kinases, thereby ensuring their precise and efficient ...

These compounds have activities as receptor-interacting protein kinase 1 (RIPK1) inhibitors and may potentially provide treatment and/or prophylaxis of inflammatory and neurodegenerative diseases ...

Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

The promoter of PKA was prepared with 4 mg forskolin powder and 1.04 ml ... chemicals were collected after 1h high temperature stress at 24°C and the total protein was prepared. Equal amounts of ...

The regulatory interactions in PKG Iβreveal similarities and differences to the way in which the cAMP-dependent protein kinase (PKA) regulatory domain inhibits the PKA catalytic subunit. The new ...