49ers vs. Cardinals prediction, odds, spread, time: 2025 NFL picks, Week 18 predictions from proven model
The San Francisco 49ers (6-10) and Arizona Cardinals (7-9) will look to wrap up their seasons on a high note when the meet Sunday in a Week 18 battle of teams that have been eliminated from the playoff picture.
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The Arizona Cardinals and San Francisco 49ers will be banged up for their Week 18 matchup at State Farm Stadium on Sunday.
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The 49ers will wrap up a massively disappointing season without a number of starters when they face the Cardinals in Week 18.
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