Fatty liver disease, caused by the accumulation of fat in the liver, is estimated to affect one in four people worldwide. If ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

Histology data included fibrosis stage, percent steatosis, inflammation grade and type, ballooning degeneration, Mallory bodies, and cholestasis. Only the initial liver biopsy was evaluated in ...

Hepatic steatosis was defined by abdominal ultrasound. A standard ultrasound unit (General Electric Logiq 400, General Electric, Milwaukee, WI, USA) was utilized to determine the presence of ...

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

All patients aged over 18 years with a hyperechoic appearance of the hepatic parenchymal structure on abdominal ultrasound suggestive of focal or diffuse steatosis of the liver were included. Results: ...

Steatotic liver disease is the overarching term for conditions characterised by abnormal lipid accumulation in the liver (liver or hepatic steatosis). Steatotic liver disease encompasses what was ...

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), has become the most prevalent chronic liver disease globally.

In patients with metabolic dysfunction-associated steatotic liver disease (MASLD), vitamin E significantly decreases serum liver inflammation markers and liver histology, according to study results ...

In addition, lower fibrosis stage was associated with notably lower risks for liver-related outcomes (HR, 0.12; 95% CI, 0.05-0.25), including HCC, liver transplant, and hepatic decompensation. However ...

Further, improvement in liver fibrosis by at least one stage without worsening of MASH was reported among 30% vs. 14% in ITT and 41% vs. 18% in mITT and by at least two stages among 20% vs. 2% in ...