A research team led by Nam Ki-taek, a professor at Yonsei University's Medical Life Sciences Department, and Jeong Ha-yeong, ...

ABSTRACT: Defensins are endogenous antimicrobial peptides (AMPs) produced by professional phago- cytes, Paneth cells, and epithelial cells at mucosal surfaces, which mediate innate immunity through ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. The role of enteric ...

Mucosal glia in human and mouse small intestines widely express Plp1. C) Whole-mount immunostaining of ileum from an adult Plp1-eGFP mouse for GFAP imaged at the level of the villus-(top panels) and ...

Introduction: The RAB11 family of small GTPases are intracellular regulators of membrane and vesicular trafficking. We recently reported that RAB11A and RAB11B redundantly regulate spindle dynamics in ...

The intestinal epithelium represents a critical interface between the host and external environment, serving as the second largest surface area in the human body after the lungs. This dynamic barrier ...

Quiescence is not a passive condition; instead, like the differentiated state, it requires ongoing active regulation to be sustained. Such transitional capacity, however, is largely lost in aging, as ...

Representative 3d rendering of the longitudinal view of one crypt of SAMR1 mouse. the epithelial layer of the crypt has been rendered in green. the Paneth cells are colored in yellow and the goblet ...

aDepartment of Pathology & Immunology, Washington University in St. Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8118, Saint Louis, MO, 63110, United States bThe F. Widjaja ...

Ma C, et al. Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis. J Crohns Colitis. Published online July 2, 2024. doi ...