Mammalian egg cells, known as oocytes, store the nutrients and materials required for early embryo development. Before fertilisation, they exist in a low-energy, almost hibernation-like state. However ...

We say: O Elvas 0-3 Vitoria de Guimaraes With O Elvas having progressed through to this round without playing a top-flight side, we have to be realistic regarding their chances.

In Vitro Gametogenesis (IVG) is another promising technology that reprograms somatic cells to create new oocytes. While MRT and IVG are still experimental, they offer hope for overcoming age ...

Endolysosomal vesicular assemblies (ELVAs) are storage compartments inside oocytes composed of lysosomes, autophagosomes (indicated by phosphatidylserine), and proteasomes that are held together by a ...

Schematic summary of the subprocesses contributing to the rejuvenation of aged oocytes by young granulosa cells. Credit: Nature Aging (2024). DOI: 10.1038/s43587-024-00697-x ...

These findings are reinforced by another recent study that independently described similar structures in mouse oocytes (Zaffagnini et al., 2024). These structures – called ELVAs by their discoverers – ...

In young oocytes, they are situated throughout the cytoplasm. Later, as oocytes mature, ELVAs fuse together, relocate and ramp up their degradative machinery. By the time an oocyte is fully mature, ...

The researchers discovered special structures in the oocytes which they named EndoLysosomal Vesicular Assemblies-or ELVAs for short. These structures -there are about 50 per each oocyte - roam the ...

But when the oocytes start maturing, ELVAs get to work and start chopping up the aggregated proteins. The team found that this cleanup is essential for correct embryo development.

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without ...