Background: Sudden cardiac death is the most frequent death mechanism in Chagas disease, responsible for 55% to 65% of the deaths of patients with chronic Chagas cardiomyopathy (CCC). The most often ...

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From the Department of Medicine, Witwatersrand University and Johannesburg Hospital and Cardio-Pulmonary Research Unit of the Council for Scientific and Industrial Research, Johannesburg, S. A.

Abstract: Electrical alternans, a beat-to-beat alternation in cardiac action potential duration, can precede dangerous arrhythmias. Alternans may arise from different mechanisms, including ...

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Aims: Microvolt T-wave alternans (TWA), an oscillation in T-wave morphology of the electrocardiogram (ECG), has been associated with increased susceptibility to ventricular tachy-arrhythmias, while ...

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Under normal conditions, the action potential duration (APD) of cardiac cells should be equal. But in a heart with cardiac alternans, APD alternates between short and long values beat-to-beat, which ...