Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP ...

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity ...

A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain’s hunger cells.

In Type 1 diabetes (T1D), insulin-producing β-cells are killed by islet-infiltrating immune cells in a process called “insulitis”. T1D results in a critical requirement for exogenous insulin and ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

Diabetes can affect many parts of your body, including heart, kidneys, eyes, feet, and legs. Various complications are possible the longer you live with the condition and if you have high blood ...

Single nucleus RNA sequencing enabled the scientists to investigate changes in the gene activity of individual cell types over the course of aging for the first time. "We were able to show that ...

This happens during cell division, when chromosomes can get left behind and not incorporated into the nucleus of a new daughter cell. A stranded chromosome forms a shoddy nuclear membrane around ...

Type 2 diabetes and prediabetes are associated with accelerated brain aging, according to a new study. The good news is that this may be counteracted by a healthy lifestyle. Type 2 diabetes and ...

The tool, AINU (AI of the NUcleus), scans high-resolution images of cells. The images are obtained with a special microscopy technique called STORM, which creates a picture that captures many ...