Amyloid immunotherapies are here, but inflammaging remains a powerful driver of neurodegenerative disease. Neuroinflammation is a rich, but thus far quite elusive, source of new drug targets. Some ...

Microvessels form the blood-brain barrier, a network that regulates molecular transfer between the vasculature and brain parenchyma. In cerebral small vessel disease (SVD), a leading cause of stroke ...

Epidemiological suggestions that the shingles vaccine might protect against dementia keep rolling in. Pascal Geldsetzer, Stanford University, presented his group’s latest findings at this year’s ...

Back in July, the U.S. POINTER study showed that a structured lifestyle makeover in older adults slightly improves scores on memory and thinking tests (Baker et al., 2025; Aug 2025 conference news).

At the turn of the 20th century, bovine tuberculosis, a bacterial disease that infected cows and spilled over to humans via milk ran rampant in France. Today, a weakened form of that same ...

Ring-shaped RNAs floating in a person’s bloodstream might mean bad news for their brain. At the 18th Clinical Trials on Alzheimer’s Disease, held December 1–4 in San Diego, Bridget Phillips, a ...

Is it three steps forward one step back for blood tests? At the 18th Clinical Trials on Alzheimer’s Disease, held December 1–4 in San Diego, new data on the FDA-approved Fujirebio Lumipulse plasma ...

At CTAD, a clinical trial of the Bacillus Calmette-Guerin vaccine in diabetes suggests a reshaping of the brain’s protein landscape in ways that might keep AD at bay.

Aβ and tau get much of the glory in Alzheimer’s disease, but the disease is far more complex than two proteins. Scientists know, for example, that lipid metabolism goes awry, but identifying ...

In Pick’s disease, as in Alzheimer’s disease and frontotemporal dementia, tangled tau spells trouble. In this subtype of FTD, abnormal clumps of three-repeat tau called Pick bodies abound in neurons.

This is a knock-in (KI) mouse model carrying a L444P mutation in the endogenous Gba (glucocerebrosidase [GC] or acid β-glucosidase) gene (Liu et al., 1998). The GBA1 protein is the lipid-degrading ...

Paper Citations Demars M, Hu YS, Gadadhar A, Lazarov O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. J Neurosci Res. 2010 Aug 1;88 ...