Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

SANTA CLARA, Calif. (KTXL) – 49ers head coach Kyle Shanahan meets with the media on Wednesday afternoon to update the status ...

SFGATE columnist Drew Magary still is beaming from the San Francisco 49ers' loss to his favorite team, the Minnesota Vikings.

San Francisco 49ers rookie wide receiver Jacob Cowing might have had his 'welcome to the NFL' moment during the team's Week 2 ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Head coach Kyle Shanahan on Wednesday confirmed in a press conference that Hufanga will get a full practice in to begin the ...

The San Francisco 49ers had a good start to their week of practice leading up to a Week 3 showdown with the Los Angeles Rams.

The San Francisco 49ers won't have wide receiver Deebo Samuel for a couple weeks because of a calf injury he sustained late ...

The San Francisco 49ers may need to do something about their backfield depth. Running back Jordan Mason has racked up 48 ...

Given that the calf strain to 49ers running back Christian McCaffrey suddenly and unexpectedly became an Achilles tendon, too ...

San Francisco 49ers head coach Kyle Shanahan reveals different preparations against the Los Angeles Rams without Aaron Donald ...

Head coach Kyle Shanahan discussed running San Francisco's offense without RB Christian McCaffrey and WR Deebo Samuel Sr., ...