In The Substance, Qualley takes on the role of Sue, a more youthful clone of Moore's aging actress who is created by an illicit serum. The film features nudity and plenty of hard to watch moments as the two women, who share one consciousness, inject themselves with the film's titular serum.

“The Substance” was lauded upon its premiere at the Cannes Film Festival earlier this year, where it was up for the Palme d’Or and won the best screenplay award. Earlier this month, it took home the Midnight Madness people’s choice award at the Toronto International Film Fest. “The Substance” is currently playing in theaters.

The provocative new film “The Substance,” about an aging celebrity (Demi Moore) who takes an illicit drug to be young again, opened on September 20 following its May premiere in competition at the Cannes Film Festival,

The new body-horror movie "The Substance" is a wild time, It also took co-stars Demi Moore and Margaret Qualley way out of their comfort zones.

"The Substance" is a dark modern fable that starts out blaming men for reducing women to sex objects and then cuts deeper. Fargeat saves a special rage for women who conspire in their own diminishment, trading their soul in a pulse beat for a few more shining hours as a goddess.

At last, Cannes embraces body-horror schlock in Coralie Fargeat's "The Substance," but the film is more metaphorical than meaningful. Review.

The body horror nightmare story is sensual, unhinged, grotesque, and will have you howling with laughter. Demi Moore has never been better.

She and costar Margaret Qualley also devoted time to perfecting sexualized gyrations their celebrity fitness characters would perform in front of leering cameras and a slimeball of a boss, played by Dennis Quaid,

The Substance’ is being distributed by MUBI, but does that mean the MUBI streaming service is where you’ll be able to watch it at home first? Demi Moore returns to the silver screen in the new body horror flick “The Substance.