Gut

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

Background Western diet and associated production of secondary bile acids (BAs) have been linked to the development of ...
Gut

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
Gut

Revised version global guidelines on diverticular disease of the colon: the Fiesole Consensus report

Introduction Colonic diverticulosis is the most common structural abnormality of the colon in developed countries, with an increasing global prevalence. Approximately 20–25% of affected individuals ...
Gut

CD177+ neutrophils: new drivers of liver regeneration

Liver resection remains the main curative option for many patients with primary and secondary liver malignancies, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma and colorectal ...
Gut

Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women

Background Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis. Objective The objective of this study was to ...
Gut

PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8 + T cell dysfunction

Background Metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) has been reported to be less responsive to immune checkpoint inhibitors, which may be associated ...
gut.bmj

Patient assessment of treatment satisfaction: methods and practical issues

Measurement of treatment satisfaction in gastro-oesophageal reflux disease (GORD) is compromised by an insufficient conceptual foundation and poor assessment methods. The current state of the art in ...
gut.bmj

Use and abuse of hydrogen breath tests

Correspondence to: Dr M Simrén Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S-41345 Göteborg, Sweden; magnus.simren{at}medicine.gu.se ...
gut.bmj

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from ...
gut.bmj

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

1 Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium 2 Department of Gastroenterology, ...
gut.bmj

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

3 Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden 4 Department of Clinical and Experimental Medicine, Division of Inflammation ...
gut.bmj

IDDF2024-ABS-0288 Engineered probiotic with high tryptophan synthesis capability protects against inflammatory bowel disease

1 Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi’an Jiao Tong University, China 2 Institute of Digestive Disease and Department of Medicine and Therapeutics, ...