Anchored Protein Kinase-A (PKA) bound to A-Kinase Anchoring Protein (AKAP) mediates the effects of localized increases in cAMP in defined subcellular microdomains and retains the specificity in ...

The activity of protein kinases is regulated by domains that are associated with the kinase core, by interacting proteins and by their incorporation into large macromolecular complexes. Thus ...

Research has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A, an enzyme which plays an essential role in memory formation ...

Critical to this "fight-or-flight" or stress response is a molecular cycle that results in the activation of protein kinase A (PKA), a protein involved in everything from metabolism to memory ...

Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8 ...

Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities ...

One gene is DNAJB1, which produces heat-shock proteins that encourage cell homeostasis, and the other is PRKACA, the generator of the catalytic subunit of protein kinase A (PKA), which is key to ...

The activation of Protein Kinase A (PKA) is a critical part in how the body responds to stress and starvation. Using a variety of imaging and biochemical techniques, a team of researchers has ...

image: Visualization of the activation of PKA (protein kinase A) involved a genetically engineered. view more Credit: UCSD. Scientists studying heart cells have devised a new way to visualize and ...

Protein Kinase A (PKA) as a Master Regulator of the Early Metabolic Reprogramming in Bone Metastatic Prostate Cancer Cells. JCO Glob Oncol 8 , 29-29 (2022). DOI: 10.1200/GO.22.35000 ...

Researchers in Korea have found new substances that are effective in restoring memory and suppressing dementia. A joint ...

One gene is DNAJB1, which produces heat-shock proteins that encourage cell homeostasis, and the other is PRKACA, the generator of the catalytic subunit of protein kinase A (PKA), which is key to ...