ANN ARBOR, Mich. – Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely ...

By learning how DKK-1blocks Wnt's signal to prostate cancer cells, they hope to learn how tocontrol physical changes in bone that encourage the development ofmetastatic tumors.

Since the discovery of WNTs 30 years ago, it has become clear that this signalling pathway is incredibly complex, using more than 15 receptors and co-receptors. What has emerged is that these ...

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Nature Communications , 2020; 11 (1) DOI: 10.1038/s41467-020-18257-3 Cite This Page : ...

Aberrant Wnt signaling has also been identified as a key mechanism in cancer biology. This article summarizes both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) ...

But Dr. Grainger says she’s discovered that there’s a co-receptor that’s involved in this particular Wnt signal and there’s already drugs targeted to that co-receptor.

Extracellular Wnt proteins activate intracellular signal transduction cascades downstream of the Fz receptor. These are classified as the canonical, or Wnt/β-catenin pathway, and the non ...

Colorectal cancer presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10%-15% of CRC cases, indicates a different clinical ...

Colorectal cancer cells exploit the Wnt signaling pathway, crucial in embryonic development, to become more aggressive. Cooperation between Wnt and the protein TBX3 activates genes that promote ...

Wnt proteins contain palmitoleic acid, an unusual lipid modification. Production of an active Wnt signal requires the acyltransferase Porcupine (Porcn) and depends on the attachment of palmitoleic ...