Hepatocellular carcinoma (HCC), the main form of primary liver cancer, is an increasingly prevalent and highly heterogeneous ...

In this context, immune cells called macrophages are a promising target in immuno-oncology, because tumor-associated macrophages (TAM macrophages) are immunosuppressive in most solid cancers, ...

A Ludwig Cancer Research study has identified a means by which cancer cells engineer the conversion of immune cells known as macrophages from destroyers of tumors to supporters of their growth and ...

Macrophages are important immune cells which produce distinct functional phenotypes in reaction to specific signals in the microenvironment, a process known as macrophage polarization. Dr.

The research has proved that CAR-M successfully resisted the influence of TAM in the mouse model and transformed into M1-type macrophages, thus exerting a tumor-killing function. It’s believed that ...

In this context, immune cells called macrophages are a promising target in immuno-oncology, because tumour-associated macrophages (TAM macrophages) are immunosuppressive in most solid cancers, i.e ...

BiME ® shows highly potent phagocytosis due to engagement of the Fc receptor on TAM and the tumor cells via TAA and SIRPα, and blockade of CD47-SIRPα “don’t eat me” signaling 1.

Tumor associated macrophages (TAMs) can facilitate the proliferation of tumor cells and are able to suppress anti-tumor immune responses within the tumor microenvironment, making them a highly ...

Methods: Primary macrophages and autologous T cells were derived from peripheral blood samples of prostate cancer patients at the University of Wisconsin. Mono-, co-, and tri-culture systems of ...

Tumor associated macrophages (TAMs) can facilitate the proliferation of tumor cells and are able to suppress anti-tumor immune responses within the tumor microenvironment, making them a highly ...