They found that CD28.ζ-CAR molecules shuttle through the immune synapse quickly, working within minutes to kill cancer cells. This enabled fast CAR T cell recovery and a mastery of “serial killing” of ...

Researchers use targeted lipid nanoparticles loaded with mRNA to reprogram T cells to fight autoimmune diseases ...

As a part of our immune defences, cytotoxic T cells -- or killer T cells -- seek out and destroy cells that are infected or cancerous. ... called the 'cytotoxic immunological synapse'.

Patients with systemic lupus erythematosus who received autologous chimeric antigen receptor T-cell therapy enjoyed potent ...

In cytotoxic T cells which cannot release potent killing chemicals, ectosomes could still be found budding across the immune synapse to target cells. A significant cytotoxic granule, ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without ...

CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic ...

"Repertoire's DECODE™ platform uniquely maps the entire immune synapse in patients and thereby enables development of transformative T cell-targeted medicines for autoimmune diseases and cancer ...

Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments. Communications Biology , 2024; 7 (1) DOI: 10.1038/s42003-024-06902-2 Cite This Page : ...

Memorial Sloan Kettering Cancer Center investigators report that T cell interferon-γ (IFNγ) orchestrates a dendritic-cell–natural-killer-cell circuit that suppresses leptomeningeal metastases ...