It was a foregone conclusion for weeks, but the Giants officially saw their postseason chances reach zero in another heartbreaking loss.

Santander’s shot off Ryan Walker (9-4) came after Casey Schmitt tied the game at 3-all with a single off Seranthony Domínguez in the top of the ninth.

Anthony Santander hit a game-ending, two-run homer with two outs in the ninth inning, and the Baltimore Orioles moved closer to a postseason berth with a 5-3 victory over the San Francisco Giants.