A consanguineous Arab pedigree in which recessive amelogenesis imperfecta (AI) and cone-rod dystrophy cosegregate, was screened for linkage to known retinal dystrophy and tooth abnormality loci by ...

Before students do Steps 5 and 6, make sure they know how to construct pedigrees. When they are ready to begin Step 5, have them select a pedigree strip. When students are finished, lead a discussion.

Inbreeding changes the equation, so to speak, because you are no longer dealing with random breeding. Instead you are bringing together individuals with the same rare complement of deleterious alleles ...