RNA molecules can be modified by enzymes through the addition or removal of chemical groups, but the roles of these modifications in the regulation of both mRNAs and non-coding RNAs are not fully ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

RNA plays critical roles in nearly all biological processes, but current methods for sequencing RNA are significantly limited. This is partially because RNA molecules are chemically modified within ...

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain ...

Researchers from Carnegie Mellon University have discovered a way to target RNA that could lead to new treatment options for myotonic dystrophy type 1 (DM1), the most common adult-onset form of ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

RNA in cells performs an astounding number of functions. Messenger RNA carries the sequences of active genes to cellular machinery that turns it into proteins. And transfer RNA molecules are an ...

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health. Small ...

Researchers have developed a powerful tool capable of scanning thousands of biological samples to detect transfer ribonucleic acid (tRNA) modifications—tiny chemical changes to RNA molecules that help ...

Hyperthermophilic archaea are true survival experts. They thrive in boiling hot springs and deep-sea vents—environments lethal to nearly all other forms of life. Subscribe to our newsletter for the ...