Pregnenolone was given orally to 17 subjects in doses ranging from 300 to 1000 mg. daily, the average daily dose being 600 mg. Pregnenolone was administered intramuscularly to 10 subjects, in ...

Pregnenolone is strongly upregulated by Δ9-tetrahydrocannabinol (THC) and limits several addictive and other effects of THC.