Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. Bottom: Intestines lacking Daam1 do not form ectopic Paneth cells, a type of secretory cells (left), while ...
Loss of Paneth cells and their antimicrobial granules has been linked to a compromised intestinal epithelial barrier, which is a hallmark of Crohn’s disease (CD). The nonclassical lymphoid cells, ...
Representative 3d rendering of the longitudinal view of one crypt of SAMR1 mouse. the epithelial layer of the crypt has been rendered in green. the Paneth cells are colored in yellow and the goblet ...
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