Life can be tricky. We have so many decisions to make. It's a good thing we have an orbitofrontal cortex and hippocampus to ...

Reciprocal connections between the orbitofrontal cortex and the basolateral nucleus of the amygdala may provide a critical circuit for the learning that underlies goal-directed behavior. We ...

The orbitofrontal cortex (OFC) is implicated in emotion and emotion-related learning. Using event-related functional magnetic resonance imaging (fMRI), we measured brain activation in human ...

More information: Wenhui Zong et al, Hippocampal output suppresses orbitofrontal cortex schema cell formation, Nature Neuroscience (2025). DOI: 10.1038/s41593-025-01928-z.

Flexible Use of Predictive Cues beyond the Orbitofrontal Cortex: Role of the Submedius Thalamic Nucleus. Journal of Neuroscience , 2015; 35 (38): 13183 DOI: 10.1523/JNEUROSCI.1237-15.2015 Cite ...

Orbitofrontal Cortex Supports Behavior and Learning Using Inferred But Not Cached Values. Science , 2012; 338 (6109): 953 DOI: 10.1126/science.1227489 Cite This Page : ...

A new study links anxiety, a brain structure called the orbitofrontal cortex, and optimism, finding that healthy adults who have larger OFCs tend to be more optimistic and less anxious.

A new study linked chronic pain to activity in the orbitofrontal cortex, an area involved in emotion regulation, self-evaluation and decision making. By Priyanka Runwal Researchers have for the ...

Your orbitofrontal cortex is a brain region located in the prefrontal cortex just behind your eyes. The region has long been known to play a role in anxiety disorders.

Phantosmia is when someone thinks they notice a smell that's not there. Sinus problems, seizures, stroke, and schizophrenia can cause phantom smells. Learn more.

The PFC consists of the front part of the frontal lobe in the cerebral cortex. It’s located right behind the eyes and is the part of the brain responsible for executive functions.. Executive functions ...

A higher burden of NLE, a thicker orbitofrontal cortex at the age of 14 years, and an accelerated orbitofrontal cortex thinning across adolescence predicted young adults' depressive symptoms.