A new study links anxiety, a brain structure called the orbitofrontal cortex (OFC), and optimism, finding that healthy adults who have larger OFCs tend to be more optimistic and less anxious.

A new study linked chronic pain to activity in the orbitofrontal cortex, an area involved in emotion regulation, self-evaluation and decision making. By Priyanka Runwal Researchers have for the ...

Partially dissociable roles of the orbitofrontal cortex and dorsal hippocampus in context-dependent hierarchical associations. Current Biology, 2024; 34 (23): 5532 DOI: 10.1016/j.cub.2024.10.049; ...

Overexpression of Shisa7 in the orbitofrontal cortex in drug-free rats induced comparable up and down changes in gene expression as that induced by the self-administration of heroin. The ...

More information: Wenhui Zong et al, Hippocampal output suppresses orbitofrontal cortex schema cell formation, Nature Neuroscience (2025). DOI: 10.1038/s41593-025-01928-z.

A higher burden of NLE, a thicker orbitofrontal cortex at the age of 14 years, and an accelerated orbitofrontal cortex thinning across adolescence predicted young adults' depressive symptoms.

In a chronic restraint stress (CRS) mouse model, THz photostimulation rapidly attenuated hyperactivity and increased serotonin levels by 107.5% ± 45.3% in lateral orbitofrontal cortex ...

Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils. Curr Biol. 2024. doi: 10.1016/j.cub.2024.06.036. This article has been republished from the ...