ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.

The Jacksonville Jaguars clinched their playoff spot during Monday Night Football when the Indianapolis Colts lost to the San Francisco 49ers. Jaguars players and fans were surely be tuned in to watch their division rival and see if they can punch their postseason pass.

Wide receiver Ricky Pearsall won’t be in the 49ers’ lineup when they face the Colts on Monday night. Pearsall missed practice all this week because of knee and ankle injuries that led the 49ers to rule him out on Saturday’s injury report. It will be the seventh game that Pearsall has missed due to injury this season.

USA Today's NFL experts make their picks for a Week 17 showdown between the Atlanta Falcons and Los Angeles Rams