The research team used melanoma cell line models resistant to BRAF inhibitors and discovered that the activation of the AMD1 gene plays a crucial role in the development of drug resistance.

GSK3-I (LY2090314) was provided to the A375 melanoma cell line as detailed in the legend of Figure 1. GSK3-I significantly reduced the viability of BRAFi-sensitive (BRAF-S) ...

New cell-based therapy for melanoma more effective than existing treatment, ... Ipilimumab is typically used in people who don’t respond to a first-line treatment called anti-PD-1 therapy; ...

TIL therapy, which uses a patient's own immune cells to fight cancer, was found in a clinical trial to work better than the existing treatment for metastatic melanoma. IE 11 is not supported.

Study: LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.Image Credit: Nemes Laszlo/Shutterstock Background. Metastasis, the migration of cancer cells from ...

New cell-based immunotherapy offered for melanoma. by Julia Evangelou Strait, Washington University School of Medicine in St. Louis ...

AMD1 inactivation sensitizes BRAF mutant melanoma to vemurafenib. Credit: Molecular Cancer (2024). DOI: 10.1186/s12943-024-02031-w ...