More information: Kauê Machado Costa et al, The role of the lateral orbitofrontal cortex in creating cognitive maps, Nature Neuroscience (2022). DOI: 10.1038/s41593-022-01216-0.

The orbitofrontal cortex encodes outcomes, expected rewards and values, but it is unclear how this region uses this information to inform action selection. Here, the authors show that lateral ...

The medial orbitofrontal cortex (reward-related OFC) and lateral orbitofrontal cortex (non-reward-related OFC) networks have different functional connectivity in patients with depression. Source ...

Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain , 2016; aww255 DOI: 10.1093/brain/aww255 Cite This Page : ...

In 2000 participants they found that smokers had low functional connectivity in general, and especially in the lateral orbitofrontal cortex, a region of the brain associated with impulsive behavior.

Analysis revealed that both poor sleep quality and depressive problems correlated to functional connectivities involving the lateral orbitofrontal cortex, the dorsolateral prefrontal cortex, the ...

More information: Lauren T. Seabrook et al, Disinhibition of the orbitofrontal cortex biases decision-making in obesity, Nature Neuroscience (2022). DOI: 10.1038/s41593-022-01210-6 Journal ...

In a chronic restraint stress (CRS) mouse model, THz photostimulation rapidly attenuated hyperactivity and increased serotonin levels by 107.5% ± 45.3% in lateral orbitofrontal cortex ...

Patients with moderate to severe depression reported significant improvements in mood when researchers precisely stimulated a brain region called the orbitofrontal cortex (OFC), according to a UC San ...

Because the lateral orbitofrontal cortex has widespread connections in the brain, the region may be especially poised to ease depression. The study focused on mood during only the brain stimulation.