"Then Daddy has to sometimes use strong language to get them to stop," NATO Secretary General Mark Rutte said.

But in oft-repeated words of main character Dr House, “It’s never lupus.” Or, with good cause, rarely ever. The making of a meme. For readers not familiar with the show, ...

The lupus meme first surfaced (he said, making a bald-faced claim with no evidence) in a 1991 episode of NBC's Seinfeld in which George expresses an irrational fear of dying from lupus. The gag ...

"Lupus was the perfect disease for us!" showrunner David Shore says with a laugh ahead of the 20th anniversary. The doctor is back in. Well, sort of. It's been 20 years since House first premiered ...

On November 16, Human Genome Sciences and GSK's Benlysta will be reviewed by a U.S. FDA advisory committee. A positive verdict should pave the way for it to become the first new treatment for ...

House creator David Shore has explained why Dr. House always diagnosed his cases with lupus first, despite the real culprit (almost) never being lupus. House's lupus diagnoses ended up becoming a ...

Below, Shore answers all of EW's lingering questions about the series, from why House's cases were (almost) never lupus to what House is up to now. Adam Taylor/NBCU Photo Bank/NBCUniversal via Getty.