The modification is histone H2B phosphorylation (in this case the process of adding a phosphate to a protein molecule) at tyrosine37 (tyrosine is one of 22 amino acids), which is critical for ...

Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that are specifically coordinated in both space and time. Histone H3 phosphorylation may initiate at different ...

A mechanism that explains how some cancer cells hijack a biological process to potentially activate cell growth has been identified by scientists. ... and in this case, histone H2B, ...

Hsu, J. Y. et al. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102 , 279–291 (2000).

Modifications to histones affect gene expression and cell fate decisions, such as those relevant to development, the brain’s reward circuitry, and memory formation, and chromatin assembly.

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-21188-2 Cite This Page : ...

It has been proposed that acetylation of the amino-terminal tails of the core histones within the nucleosome particle is critical for activating transcription. In the December Genes and Development, ...

Researchers have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings ...