In addition, there is only one known sequence variant and H4 has a modest and simpler PTM profile than other histones. ... and also resolved histone H1 phosphorylated isoforms.

Histone H1.2 and PARP1 interact with mutant FUS, contributing to ALS-related neurodegeneration; inhibiting these proteins reduces FUS aggregation. The study's findings are relevant to both familial ...

The study, "Histone H1 Phosphorylation Is Associated With Transcription by RNA Polymerases I and II," is available online, or from the U. of I. News Bureau. Journal. Journal of Cell Biology.

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes. Cell Reports , 2024; 43 (8): 114626 DOI: 10.1016/j.celrep.2024.114626 Cite This Page : ...

Megha Talati 1, Erin Seeley 2, Kaori Ihida-Stansbury 3, Horace Delisser 3, Hayes McDonald 2, Fei Ye 4, Xueqiong Zhang 4, Yu Shyr 4, Richard Caprioli 2, Barbara Meyrick 5, Altered expression of nuclear ...

H1 Histone Protein (IMAGE) University of Illinois at Urbana-Champaign, News Bureau. Caption. Here are three views of the same human cells with different staining of the nucleus. In the ...

Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. The Journal of Cell Biology , 2010; 189 (3): 407 DOI: 10.1083/jcb.201001148 Cite This Page : ...

University of Cologne scientists identified histone H1.2 and PARP1 as potential therapeutic targets in ALS. Inhibiting these proteins reduced neurodegeneration in both human motor neurons and C.