A study reveals that children with autism and ADHD have greater difficulty eliminating BPA, increasing their exposure to ...

Oncotarget published "Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer" which reported that Glucuronidation controls ...

Treatment with drugs that induce glucuronidation enzymes, including phenobarbital, phenytoin, carbamazepine, and rifampin, sometimes necessitates an increase in the dose of levothyroxine. 55,56 ...

Codeine is bioactivated by CYP2D6 into morphine, which then undergoes further glucuronidation. CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent ...

Acta Pharmacologica Sinica - The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants Skip to main content Thank you for visiting nature.com.

The number of people being diagnosed with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) has risen sharply in recent decades, and research continues to look at ...

Glucuronidation reactions in humans represent an important detoxification process for exogenous as well as endogenous compounds such as steroids, bile acids, environmental toxicants, hormones ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Smith, Yolanda. (2021, April 06). Toxicity of Metabolites.

Background: The uridine diphosphate-glucuronsyltransferase 1A (UGT1A) family of enzymes is involved in the phase II biotransformation of various drugs, including the irinotecan metabolite, SN-38. The ...

Furthermore, glucuronidation of SN-38 may also be in part responsible for the large interpatient variability in the total SN-38 AUC. Conversely, low intrapatient variation of this parameter was ...