Additionally, research into fructose-1,6-bisphosphatase deficiency, caused by mutations in the FBP1 gene, has shown how genetic defects can lead to metabolic disturbances that may manifest as ...
In an effort to find safe and efficacious GNG inhibitors, we targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase). The hydrophilic nature of AMP binding sites and their widespread ...
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