High point totals mean opportunity, and several key matchups stand out as potential fantasy goldmines in Week 10. Week 10 of the NFL season is already upon us, and the challenge of setting lineups and finding an edge in fantasy football only becomes greater than the week before.

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.

At 6-2, 6-2, and 6-3, the NFC West looks destined to send three teams to the playoffs, but the winner of the division could be determined on which team wins the trade deadline on Tuesday. Either by making a huge acquisition or by sitting out and trusting their players and coaches to win an explosive second half showdown between these three teams.