Because D1-like receptors were increased equally in the NAcc core and shell in pair bonded voles, micro-injection volume was increased to 500 nl per side; this allowed sufficient upward diffusion ...

Phencyclidine (PCP) is an example of a drug that does not activate the dopamine system; it triggers reward in NACC by blocking the glutamate (NMDA) receptors on the GABAergic neurons, but bypasses ...

The THC in cannabis stimulates cannabinoid receptors on the GABA neurons, thus turning off the continuous inhibition of dopamine neurons. Voila—you are now euphoric.

When dopamine binds to D1 receptors, it helps enhance signal processing in areas of the brain crucial for focus and attention. On the other hand, D2 receptors are more involved in modulating the ...

Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors produced by drugs of abuse. Thus, adenosine receptor stimulation provides a “brake” ...

Nicolas X. Tritsch, Motivating interest in D3 dopamine receptors, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01820-2. Journal information: Nature Neuroscience ...

These receptors and the cells that express them mediate opposite approach/avoidance responses, and are differentially impacted by dopamine transmission in that region of the brain.

These receptors and the cells that express them mediate opposite approach/avoidance responses, and are differentially impacted by dopamine transmission in that region of the brain.