Spinocerebellar ataxias are a very heterogeneous group of inherited diseases associated with degeneration of the cerebellum ... and specific symptoms when patients are so different from one another?

Several of the spinocerebellar ataxias (SCAs) result from expansion of polyglutamine (polyQ)-encoding regions in different genes. Here, Orr and colleagues examine the clinical features of the the ...

Scientists have examined more than a century of data of the genetic makeup of ataxias, a neurodegenerative disorder, to better understand the different forms of this devastating disease and how it ...

Acute cerebellar ataxia (ACA) is a disorder that occurs when the cerebellum becomes inflamed or damaged. The cerebellum is the area of the brain responsible for controlling gait and muscle ...

When he discovered the gene, Dr. Stefan Pulst thought the therapy would come quickly but finding the gene was only the beginning of the journey. After meeting a family with a different type of nervous ...

Autosomal recessive cerebellar ataxias are heterogeneous, ... The same phenotype of autosomal recessive cerebellar ataxia may be due to different diseases (e.g., Friedreich's ataxia or ataxia with ...

The inherited ataxias are a large, heterogeneous group of neurodegenerative disorders caused by a variety of gene mutations, the effects of which are exerted through different pathogenic ...

Cells can remain functional despite damage to mitochondria Date: August 31, 2020 Source: Max-Planck-Gesellschaft Summary: Mitochondria are the power plants of our cells and play an important role ...

Ataxia is managed by a team of specialists in different fields. This is called the multi-disciplinary team. ... Ataxias caused due to infections for example may be treated with antibiotics.

In our increasingly ageing society, neurodegenerative diseases are posing a significant burden. A growing body of evidence has linked mitochondrial dysfunction to some of the most devastating forms of ...