When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

A team has unlocked a decades old mystery about how a critical cellular process called DNA replication is regulated. A team of Florida State University researchers has unlocked a decades-old mystery ...

Researchers have identified the mechanism used by the helicase ring to thread around and separate entwined DNA strands in the replication process. DNA replication is a complex process in which a ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...