Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. Bottom: Intestines lacking Daam1 do not form ectopic Paneth cells, a type of secretory cells (left), while ...
Representative 3d rendering of the longitudinal view of one crypt of SAMR1 mouse. the epithelial layer of the crypt has been rendered in green. the Paneth cells are colored in yellow and the goblet ...
Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...
Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, scientists identified a new ...
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