(HealthDay)—β2-adrenergic receptor (β-AR) signaling in host immune cells regulates CD8+ T-cell frequency and functional orientation within the tumor microenvironment, according to a study ...

Beta-adrenergic signaling mechanisms are of central importance to cardiovascular health and disease. Modulation of these pathways represents an important pharmacologic approach to the treatment of ...

Shane Wright, Assistant Professor at the Department of Physiology and Pharmacology, and colleagues have uncovered a new way ...

Other signaling molecules must therefore be activated downstream of beta1-AR, and the authors suggest that targeting the signaling molecules downstream of beta-ARs might provide a new approach to ...

Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated from a second PAG binding site that acts as a custom "dimmer switch” for the adrenaline signaling pathway.

The new study unveiled an elegant intracellular signaling system in which beta-receptor activation modulates alpha-adrenergic signaling. It showed that blocking the beta-receptor alone promotes ...

In a 2023 paper, we determined that sympathetic nerves secrete catecholamines that activate beta-adrenergic receptor signaling in bone marrow stromal cells responsible for producing the growth ...

Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated by a second PAG binding site that acts as a custom "dimmer switch" for the adrenaline signaling pathway.

Wang’s study “β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade,” was recently published in Science Translational Medicine. She collaborated with other members ...

“Beta3 has unique signaling pathways not shared by other beta-adrenergic receptors,” said Dr. Borja Ibáñez, scientific director at the Centro Nacional de Investigaciones Cardiovasculares, a ...