Vasopressors can act on the alpha-1, beta-1, and beta-2 adrenergic receptors. They also can act on dopamine receptors. These drugs stimulate smooth muscle contraction in the blood vessels.

Beta-adrenergic signaling mechanisms are of central importance to cardiovascular health and disease. Modulation of these pathways represents an important pharmacologic approach to the treatment of ...

Cardiac sympathetic nerve terminals release norepinephrine, which binds to β-adrenergic receptors throughout the atria and ventricles. Norepinephrine released from the nerve diffuses through the ...

Based on the structure of these compounds and the characterization of the structural interaction between ‘9087 and the α 2a-adrenergic receptor, the researchers further developed additional ...

The adrenaline receptor studied is a member of the G protein-coupled receptor (GPCR) family, and this family is the target of one-third of all Food and Drug Administration (FDA)-approved drugs.

The addition of β-adrenergic antagonists to the treatment regimen for heart failure has validated the neurohormonal hypothesis and provided much-improved outcomes. This benefit had been in ...

Background: The β2-adrenergic receptor (ADRB2) plays a major role in regulating energy expenditure by stimulating lipid metabolism in human adipose tissue. Polymorphisms in the ADRB2 gene have ...

A novel GPS NMR method enabled precise tracking of motions within the β 1-adrenergic GPCR, revealing that the receptor exists in a dynamic equilibrium among inactive, preactive, and active states.

Researchers from Centro Nacional de Investigaciones Cardiovasculares found stimulation of the beta-3 adrenergic receptor in heart cells helps protect and prevent heart failure from aortic ...

Aug. 24, 2009— -- Question: What are adrenergic agonists, when are they used to treat glaucoma, and what are the risks/benefits? Answer: Adrenergic agonist is another type of class of ...

A rare mutation of ß1-adrenergic receptor affects sleep/wake behaviors [published online August 28, 2019]. Neuron . doi: 10.1016/j.neuron.2019.07.026. Newsletter ...

APD418 is a first-in-class β3 adrenergic receptor selective antagonist and cardiac myotrope that is expected to improve cardiac contractility with little effect on heart rate, ...