The depletion of FOXM1 or ABCC5 with siRNA significantly blocked drug efflux and increased the intracellular concentrations of paclitaxel, thereby promoting paclitaxel-induced cell death.

The blue area is on behalf of ABCC5, with ABCC5-AS1 (ABCC5 antisense RNA 1) shown in the purple area. The red line indicates the location of rs1401999 in the study. (Image referenced from GWAS4D ...

The monoglutamated forms and, to some extent, polyglutamated forms are expelled via transporters ABCC1-ABCC5 and ABCG2. ABCB1 does not transport anionic drugs such as methotrexate.

Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has ...

ABCC5, which encodes a carrier protein for intracellular secondary messenger transport, might affect the development of axial length and refraction by regulating the secondary messenger cAMP pathway.