The Charlotte 49ers faced one of their new American Athletic Conference opponents in just the second meeting between the ...

Charlotte 49ers fans tailgated ahead of the ECU home football game on Oct. 5. The 49th acre featured individual tailgates ...

The Charlotte 49ers couldn’t upend the in-state power up the highway. The North Carolina Tar Heels pounded the gas pedal in their 38-20 victory over Charlotte on Saturday. UNC controlled its ...

McCaffrey is a do-it-all back that gives defenses fits. The 49ers have talent all over their offense but it starts with McCaffrey. He rushed for 1,459 yards and 14 touchdowns last season and had ...

Minnesota Vikings wide receiver Justin Jefferson's 97-yard touchdown reception in the Vikings' 23-17 win over the San Francisco 49ers was the longest scoring play of Week 2 through Sunday.

The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

It's not often that you see an NFL game end with a final score that's never happened in league history, but that's exactly what the Jets and 49ers gave us Monday night in San Francisco.

There was a moment. There was. The Jets defense had registered a stop, then stiffened after a Breece Hall fumble deep in their own end, holding the 49ers to a field goal. Now it was Aaron Rodgers ...

The San Francisco 49ers apparently came extremely close to trading Brandon Aiyuk to the Pittsburgh Steelers. The team was actually on the phone with the Steelers when Aiyuk arrived at the 49ers ...

There is a slight chance that Fred Warner and George Kittle aren't available for the 49ers against the Cardinals in Week 5. The 49ers' injury report was released today with five players listed as ...

Christian McCaffrey is eligible to return from injured reserve, but the running back is not ready to return. The 49ers will not activate McCaffrey for Thursday Night Football, Adam Schefter of ESPN ...